Skip to Content
Home > Patients & Visitors > Health Library > Antidepressants for Migraine Headaches
Antidepressant medicines, which are usually used to treat
depression, can be effective in preventing migraine
headaches. Antidepressants have some pain-relieving properties and may reduce
duration and frequency of headaches. Antidepressants are also used to improve
Tricyclic antidepressants are used most to prevent
migraines. Amitriptyline and nortriptyline are used most often.
Other antidepressants may be tried if you do not respond well
to amitriptyline or nortriptyline. The choice of antidepressant to treat your
migraines may depend on your ability to tolerate the side effects of the
Side effects of tricyclic antidepressants
Never suddenly stop taking antidepressants. The use of any
antidepressant should be tapered off slowly and only under the supervision of a
doctor. Abruptly stopping antidepressant medicine can cause negative side
effects or a relapse into a depressive episode or panic disorder.
FDA advisories. The U.S. Food and
Drug Administration (FDA) has issued:
Current as of:
April 17, 2014
Anne C. Poinier, MD - Internal Medicine & Colin Chalk, MD, CM, FRCPC - Neurology
How this information was developed to help you make better health decisions.
To learn more, visit Healthwise.org
© 1995-2014 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Feeling under the weather?
Use our interactive symptom checker to evaluate your symptoms and determine appropriate action or treatment.
Our interactive Decision Points guide you through making key health decisions by combining medical information with your personal information.
You'll find Decision Points to help you answer questions about:
Get started learning more about your health!
Our Interactive Tools can help you make smart decisions for a healthier life. You'll find personal calculators and tools for health and fitness, lifestyle checkups, and pregnancy.
Send Us Your Feedback
North Kansas City Hospital.