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Trisomy X

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Trisomy X is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • 47, XXX
  • 47, XXX karyotype
  • 47, XXX syndrome
  • triple X syndrome
  • triplo X
  • XXX syndrome

Disorder Subdivisions

  • None

General Discussion

Trisomy X is a disorder that affects females and is characterized by the presence of an additional X chromosome. Normally, females have two X chromosomes; however, females with trisomy X carry three X chromosomes in the nuclei of body cells. There are specific physical features (phenotype) associated with this chromosomal disorder. Common symptoms that can potentially occur include language-based learning disabilities, developmental dyspraxia, tall stature, low muscle tone (hypotonia), and abnormal bending or curving of the pinkies toward the ring fingers (clinodactyly). Trisomy X occurs randomly as a result from errors during the division of reproductive cells in one of the parents. This disorder occurs in one in 900 to 1,000 live births.

Resources

March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
Tel: (914)997-4488
Fax: (914)997-4763
Tel: (888)663-4637
Email: Askus@marchofdimes.com
Internet: http://www.marchofdimes.com

National Dissemination Center for Children with Disabilities (DELETED
1825 Connecticut Ave NW, Suite 700
Washington, DC 20009
USA
Tel: (202)884-8200
Fax: (202)884-8441
Tel: (800)695-0285
TDD: (800)695-0285
Email: nichcy@aed.org
Internet: http://www.nichcy.org

National Center for Learning Disabilities
381 Park Avenue South
1420 Suite
New York, NY 10016
Tel: (212)545-7510
Fax: (212)545-9665
Tel: (888)575-7373
Email: ncld@ncld.org
Internet: http://www.ncld.org/

Chromosome Disorder Outreach, Inc.
P.O. Box 724
Boca Raton, FL 33429-0724
USA
Tel: (561)395-4252
Fax: (561)395-4252
Email: info@chromodisorder.org
Internet: http://www.chromodisorder.org/CDO/

Learning Disabilities Association of America
4156 Library Road
Pittsburgh, PA 15234-1349
Tel: (412)341-1515
Fax: (412)344-0224
Tel: (888)300-6710
Email: info@ldaamerica.org
Internet: http://www.ldanatl.org

International Dyslexia Association
40 York Rd
4 Florr
Baltimore, MD 21204
USA
Tel: (410)296-0232
Fax: (410)321-5069
Tel: (800)222-3123
Email: info@interdys.org
Internet: http://www.interdys.org

UNIQUE - Rare Chromosome Disorder Support Group
P.O. Box 2189
Caterham
Surrey, CR3 5GN
United Kingdom
Tel: 4401883330766
Fax: 4401883330766
Email: info@rarechromo.org
Internet: http://www.rarechromo.org

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/

Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766
Email: getinfo@madisonsfoundation.org
Internet: http://www.madisonsfoundation.org

Klinefelter Syndrome & Associates
P.O. Box 872
Pine, CO 80470-0872
Tel: (303)400-9040
Fax: (303)838-0753
Tel: (888)999-9428
Email: info@genetic.org
Internet: http://www.genetic.org

Focus Foundation, Inc.
PO Box 190
Davidsonville, MD 21035
Tel: (443)223-7323
Fax: (410)798-4801
Email: info@thefocusfoundation.org
Internet: http://www.thefocusfoundation.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  4/1/2014
Copyright  1995, 1996, 1997, 1998, 2001, 2011, 2014 National Organization for Rare Disorders, Inc.

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