Addison's Disease

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Addison's Disease is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Addison's disease is a rare disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of cells of the adrenal glands (adrenal cortex). The symptoms of classic Addison's disease, also known as primary adrenal insufficiency, result from the insufficient production of these two hormones, cortisol and aldosterone. Major symptoms include fatigue, gastrointestinal abnormalities, and changes in skin color (pigmentation). Behavior and mood changes may also occur in some individuals with Addison's disease. Increased excretion of water and low blood pressure (hypotension) can lead to extremely low concentrations of water in the body (dehydration). The symptoms of Addison's usually develop slowly, but sometimes can develop rapidly, a serious condition called acute adrenal failure. In most cases, Addison's disease occurs when the body's immune system mistakenly attacks the adrenal glands causing slowly progressive damage to the adrenal cortex.

Supporting Organizations

Addison's Disease Self-Help Group (UK)

P.O. Box 1083
Guildford, Surrey, GU1 9HX
United Kingdom
Email: info@addisons.org.uk
Website: http://www.addisons.org.uk

American Autoimmune & Related Diseases

22100 Gratiot Ave.
Eastpointe, MI 48021
Tel: (586)776-3900
Fax: (586)776-3903
Tel: (800)598-4668
Email: aarda@aarda.org
Website: http://www.aarda.org/

AutoImmunity Community

Website: https://www.facebook.com/autoimmunityforum

CARES Foundation, Inc.

2414 Morris Avenue, Suite 110
Union, NJ 07083
Tel: (908)364-0272
Fax: (908)686-2019
Tel: (866)227-3737
Email: contact@caresfoundation.org
Website: http://www.caresfoundation.org

Congenital Adrenal Hyperplasia Support Group

PO Box 66
Waihi
Hauraki, 3641
New Zealand
Tel: 6433584507
Fax: 6433584506
Tel: 800224698
Email: CAHNZ@snap.net.nz
Website: http://www.cah.org.nz/

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Website: http://rarediseases.info.nih.gov/GARD/

Hormone Health Network Endocrine Society

2055 L Street NW
Suite 600
Washington, DC 20036
Tel: (202)971-3636
Fax: (202)736-9705
Tel: (888)363-6274
Email: hormone@endocrine.org
Website: http://www.hormone.org/

Hypoparathyroidism Association, Inc.

PO Box 2258
Idaho Falls, ID 83403
Tel: (208)524-3857
Fax: (205)524-3857
Tel: (866)213-0394
Email: jsanders@hypopara.org
Website: http://www.hypopara.org

MedicAlert Foundation International

2323 Colorado Avenue
Turlock, CA 95382
USA
Tel: (209)669-2401
Fax: (209)669-2456
Tel: (888)633-4298
Email: Inquiries@medicalert.org
Website: http://www.medicalert.org

NIH/National Institute of Diabetes, Digestive & Kidney Diseases

Office of Communications & Public Liaison
Bldg 31, Rm 9A06
Bethesda, MD 20892-2560
Tel: (301)496-3583
Email: NDDIC@info.niddk.nih.gov
Website: http://www2.niddk.nih.gov/

National Adrenal Diseases Foundation

505 Northern Bloulevard
Great Neck, NY 11021
USA
Tel: (516)487-4992
Fax: (516)829-5710
Email: nadfmail@nadf.us
Website: http://www.nadf.us/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  5/1/2015
Copyright  2015 National Organization for Rare Disorders, Inc.