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Angioimmunoblastic T-Cell Lymphoma

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Angioimmunoblastic T-Cell Lymphoma is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • AILD
  • AITL
  • angioimmunoblastic lymphadenopathy with dysproteinemia
  • immunoblastic lymphadenopathy
  • lymphogranulomatosis X

Disorder Subdivisions

  • None

General Discussion

Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkin lymphoma, which is a group of related malignancies (cancers) that affect the lymphatic system (lymphomas). The lymphatic system functions as part of the immune system and helps to protect the body against infection and disease. It consists of a network of tubular channels (lymph vessels) that drain a thin watery fluid known as lymph from different areas of the body into the bloodstream.

Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. As lymph moves through the lymphatic system, it is filtered by a network of small structures known as lymph nodes that help to remove microorganisms (e.g., viruses, bacteria, etc.) and other foreign bodies. Groups of lymph nodes are located throughout the body, including in the neck, under the arms (axillae), at the elbows, and in the chest, abdomen, and groin. Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. In addition to the lymph nodes, the lymphatic system includes the spleen, which filters worn-out red blood cells and produces lymphocytes, and bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body. There are two main types of lymphocytes: B-lymphocytes (B-cells), which may produce specific antibodies to "neutralize" certain invading microorganisms, and T-lymphocytes (T-cells), which may directly destroy microorganisms or assist in the activities of other lymphocytes.

AITL results from errors in the production of a T-cell or transformation of a T-cell into a malignant cell. Abnormal, uncontrolled growth and multiplication (proliferation) of malignant T-cells may lead to enlargement of a specific lymph node region or regions; involvement of other lymphatic tissues, such as the spleen and bone marrow; and spread to other bodily tissues and organs. A key and differentiating aspect of AITL is dysfunction of the immune system, which can lead to a variety of symptoms. Individuals with AITL may develop a rash, persistent fever, unintended weight loss, tissue swelling due to the accumulation of fluid (edema) and additional symptoms. The exact, underlying cause of AITL is not fully understood.

Resources

Leukemia & Lymphoma Society
1311 Mamaroneck Avenue
Suite 310
White Plains, NY 10605
Tel: (914)949-5213
Fax: (914)949-6691
Tel: (800)955-4572
Email: infocenter@LLS.org
Internet: http://www.LLS.org

American Cancer Society, Inc.
250 Williams NW St
Ste 6000
Atlanta, GA 30303
USA
Tel: (404)320-3333
Tel: (800)227-2345
TDD: (866)228-4327
Internet: http://www.cancer.org

National Cancer Institute Physician Data Query
Office of Communications and Education
Public Inquiries Office
6116 Executive Blvd
Suite 300
Bethesda, MD 20892-8322
Tel: (800)422-6237
Email: cancergovstaff@mail.nih.gov
Internet: http://www.cancer.gov/cancertopics/pdq/cancerdatabase

NIH/National Institute of Allergy and Infectious Diseases
Office of Communications and Government Relations
6610 Rockledge Drive, MSC 6612
Bethesda, MD 20892-6612
Tel: (301)496-5717
Fax: (301)402-3573
Tel: (866)284-4107
TDD: (800)877-8339
Email: ocpostoffice@niaid.nih.gov
Internet: http://www.niaid.nih.gov/

National Cancer Institute
6116 Executive Blvd Suite 300
Bethesda, MD 20892-8322
USA
Tel: (301)435-3848
Tel: (800)422-6237
TDD: (800)332-8615
Email: cancergovstaff@mail.nih.gov
Internet: http://www.cancer.gov

Cancer Hope Network
2 North Road
Suite A
Chester, NJ 07930
Tel: (908)879-4039
Fax: (908)879-6518
Tel: (800)552-4366
Email: info@cancerhopenetwork.org
Internet: http://www.cancerhopenetwork.org

OncoLink: The University of Pennsylvania Cancer Center Resource
3400 Spruce Street
2 Donner
Philadelphia, PA 19104-4283
USA
Tel: (215)349-8895
Fax: (215)349-5445
Email: hampshire@uphs.upenn.edu
Internet: http://www.oncolink.upenn.edu

Lymphoma Research Foundation
115 Broadway
Suite 1301
New York, NY 10006
USA
Tel: (212)349-2910
Fax: (212)349-2886
Tel: (800)235-6848
Email: LRF@lymphoma.org
Internet: http://www.lymphoma.org

Lymphoma Foundation Canada
16-1375 Southdown Road
Suite 236
Mississauga
Ontario, L5J 2Z1
Canada
Tel: 9058225135
Fax: 9058149152
Tel: 8666595556
Email: info@lymphoma.ca
Internet: http://www.lymphoma.ca

Lymphoma Association (UK)
PO Box 386
Aylesbury, HP20 2GA
United Kingdom
Tel: 01296619400
Email: information@lymphomas.org.uk
Internet: www.lymphomas.org.uk

International Cancer Alliance for Research and Education (ICARE)
4853 Cordell Avenue
Suite 14
Bethesda, MD 20814
Tel: (301)656-3461
Fax: (301)654-8684
Tel: (800)422-7361
Email: info@icare.org
Internet: http://www.icare.org

Cancer Care, Inc.
275 Seventh Avenue
New York, NY 10001
Tel: (212)712-8400
Fax: (212)719-0263
Tel: (800)813-4673
Email: info@cancercare.org
Internet: http://www.cancercare.org

Rare Cancer Alliance
1649 North Pacana Way
Green Valley, AZ 85614
USA
Internet: http://www.rare-cancer.org

Friends of Cancer Research
1800 M Street NW
Suite 1050 South
Washington, DC 22202
Tel: (202)944-6700
Email: info@focr.org
Internet: http://www.focr.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  2/16/2011
Copyright  1988, 1989, 2000, 2011 National Organization for Rare Disorders, Inc.

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