Neonatal-onset Multisystem Inflammatory Disease

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Neonatal-onset Multisystem Inflammatory Disease is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Neonatal-onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurologic cutaneous articular (CINCA) syndrome, is a rare, congenital, systemic, inflammatory condition distinguished by fever, rash, joint disease, and central nervous system (CNS) disease. The hallmark of NOMID is onset during infancy or early childhood.

NOMID is the most severe form of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. These syndromes are characterized by fever, rash, and joint pain.

Supporting Organizations

Autoinflammatory Alliance

P.O. Box 590354
San Francisco, CA 94118
Tel: (415)831-8782

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311

NIH/Office of Rare Disease Research

6701 Democracy Boulevard
Suite 1001, MSC 4874
Bethesda, MD 20892-7518
Tel: (301)402-4336
Fax: (301)480-9655

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  6/30/2015
Copyright  2011 National Organization for Rare Disorders, Inc.