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Mad cow disease is a fatal disease that
slowly destroys the brain and spinal cord (central nervous system) in cattle. It also is known as bovine spongiform encephalopathy,
People cannot get mad cow disease. But in rare cases they
may get a human form of mad cow disease called variant Creutzfeldt-Jakob
disease (vCJD), which is fatal.
This can happen if you eat nerve
tissue (the brain and spinal cord) of cattle that were infected with mad cow
disease. Over time, vCJD destroys the brain and spinal cord.
is no evidence that people can get mad cow disease or vCJD from eating muscle
meat—which is used for ground beef, roasts, and steaks—or from consuming milk
or milk products.
People with vCJD cannot spread it to others
through casual contact.
People who have spent a lot of time (at least 3 months) in places where mad cow disease has been found are not
allowed to give blood in the United States or Canada.2, 1 This is to help prevent vCJD from
Experts are not sure what causes mad cow disease
The leading theory is that the disease is caused by infectious
proteins called prions (say "PREE-ons"). In affected cows, these proteins are
found in the brain, spinal cord, and small intestine. There is no proof that
prions are found in muscle meat (such as steak) or in milk.
cow is slaughtered, parts of it are used for human food and other parts are
used in animal feed. If an infected cow is slaughtered and its nerve tissue is
used in cattle feed, other cows can become infected.
get vCJD if they eat the brain or spinal cord tissue of infected cattle.
case of vCJD was reported in 1996. Since then, there have been a few cases of
vCJD reported in the world. Most of the cases have been in countries that are
part of the United Kingdom (England, Scotland, Wales, and Northern
In December 2003, mad cow disease was discovered in one
cow in the United States. Before this cow was found to have the disease, the
cow was slaughtered and its muscle meat was sent to be sold in grocery stores.
But its organs and nerve tissue were not used for human food. Although mad cow
disease cannot be spread through muscle meat, the United States Department of
Agriculture (USDA) quickly traced the meat and removed it from grocery stores.
Since 2004, only three more cows
in the United States have been found to have mad cow disease. The most recent case of BSE was found in April 2012 in a cow in California.
Creutzfeldt-Jakob disease (vCJD) causes the brain to become damaged over time.
It is fatal. Symptoms include:
If a person does eat nerve tissue from an infected
cow, he or she may not feel sick right away. The time it takes for symptoms to
occur after you're exposed to the disease is not known for sure, but experts
think it is years.
There is no single test to
diagnose vCJD. Doctors may think that a person has vCJD based on where the
person has lived and the person's symptoms and past health. Imaging tests, such
MRI, may be done to check for brain changes caused by
Researchers are now trying to develop a blood test that
looks for vCJD. But no blood test is available at this time.
brain biopsy is the only way to confirm a diagnosis of vCJD.
There is no cure for vCJD.
Treatment includes managing the symptoms that occur as the disease gets worse.
The following health
organizations are tracking and studying
mad cow disease and variant Creutzfeldt-Jakob disease
(vCJD). Their websites contain the most up-to-date information about these
Canadian Blood Services (2005). Deferral policies for vCJD. Available online: http://www.bloodservices.ca/CentreApps/Internet/UW_V502_MainEngine.nsf/page/Deferral+Policies+for+vCJD?OpenDocument.
American Red Cross (2009). Eligibility requirements: Donating blood. Available online: http://www.redcrossblood.org/donating-blood/eligibility-requirements.
Other Works Consulted
Bosque PJ, Tyler KL (2010). Prions and prion diseases of the central nervous system (transmissible neurodegenerative diseases). In GL Mandell et al., eds., Mandell, Douglas, and Bennett's Principles and
Practice of Infectious Diseases, 7th ed., vol. 2, pp. 2423–2438.
Philadelphia: Churchill Livingstone.
U.S. Centers for Disease Control and Prevention (2010). Fact sheet: Variant Creutzfeldt-Jakob disease. Available online: http://www.cdc.gov/ncidod/dvrd/vcjd/factsheet_nvcjd.htm.
ByHealthwise StaffPrimary Medical ReviewerE. Gregory Thompson, MD - Internal MedicineSpecialist Medical ReviewerW. David Colby IV, MSc, MD, FRCPC - Infectious Disease
Current as ofNovember 14, 2014
Current as of:
November 14, 2014
E. Gregory Thompson, MD - Internal Medicine & W. David Colby IV, MSc, MD, FRCPC - Infectious Disease
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