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Photodynamic therapy (PDT) is a treatment used for
nonmelanoma skin cancer. PDT is a process. First a medicine is applied to the skin. Then the doctor shines a special light on it. PDT may be used to treat skin cancers when surgery or radiation can't be used.
Medicines used in PDT for skin cancer include 5-aminolevulinic acid (ALA), methyl aminolevulinate (MAL), and porfirmer sodium.
PDT is used to treat
actinic keratoses on the face and scalp. It's also used to treat
squamous cell carcinoma in situ (Bowen's disease) and superficial
basal cell carcinomas. Studies show that cure rates for skin cancers treated with PDT may be slightly lower than with surgery or radiation. But PDT does not leave a scar like surgery does.1
Studies of PDT with the medicine MAL found that this treatment worked as well as cryosurgery for actinic keratoses and squamous cell carcinoma in situ (Bowen's disease).2
National Comprehensive Cancer Network (2012). Basal cell and squamous cell skin cancers. NCCN Clinical Practice Guidelines in Oncology, Version 2. Available online: http://www.nccn.org/professionals/physician_gls/PDF/nmsc.pdf.
National Comprehensive Cancer Network (2010). Basal cell and squamous cell skin cancers. NCCN Clinical Practice Guidelines in Oncology, Version 1. Available online: http://www.nccn.org/professionals/physician_gls/PDF/nmsc.pdf.
Current as of:
September 17, 2013
E. Gregory Thompson, MD - Internal Medicine & Amy McMichael, MD - Dermatology
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